What is the relationship between creatinine high and glomerular?
ă€€ă€€Blood-muscle-liver index is one of the main methods used to detect renal function in clinic. Human muscle metabolism produces creatine, and creatine mainly through the irreversible non-enzymatic dehydration reaction slowly constitute creatinine, and then released into the blood, that is often said blood muscle liver. With the blood circulation system operation of the muscle liver substances through the kidney, filtered by the kidneys and urine excretion, constitute a normal urine urine creatinine. As a result, blood creatinine is closely related to the total amount of muscle in the body, but it is not related to the food and eating habits of the human body. The blood muscle liver belongs to the small molecule material, may through the human kidney glomerular filtration barrier but rarely by the kidney small tube heavy absorption. That situation shows that the body of the daily production of creatinine, almost all with urine excretion, generally not affected by urine volume.
ă€€ă€€When the kidney function examination, if appears the blood creatinine value surpasses the normal range the phenomenon, may be the patient has the kidney failure, uremia, heart failure and so on. The level of blood muscle liver is not related to the factors such as human diet, high catabolism and so on. With the stability of exogenous creatinine intake and the constant of endogenous creatinine composition, the increase of blood muscle liver depends mainly on glomerular filtration function of kidney.
ă€€ă€€such as the glomerular filtration function is normal, the detection of human blood muscle liver indicators are also appropriate, such as glomerular filtration function to a certain extent, the blood muscle liver value will increase. glomerular filtration rate is an important index to evaluate glomerular filtration function, but when glomerular filtration rate drops to a certain extent, the blood muscle liver value of the human body does not increase accordingly. Only when the glomerular filtration rate drops to more than 1/3 of the normal condition, the blood-muscle liver will show an obvious upward trend. That data suggests that the rise in blood-muscle liver levels in the human body lags far behind the glomerular damage. That is because the human kidney itself has a very powerful compensatory function, a small number of glomerular fibrosis, sclerosis degeneration, the remaining majority of healthy glomerular will replace these lesions of the glomerular continue to work.
ă€€ă€€Unless the majority of the kidney in the kidneys have been hardening, degeneration, glomerular filtration rate will begin to decline significantly, at this time, kidney disease patients will appear clinically uncomfortable symptoms, such as high blood pressure, anemia, malaise and so on. On the other hand, in the kidney more than 70% of the glomerular fibrosis, sclerosis degeneration, that is, renal function has been damaged more than 50% of the kidney, blood and liver indicators will appear in the clinical trend of increased.
ă€€ă€€In other words, kidney function may have been lost more than 50% when the blood-muscle liver of a kidney patient begins to rise. To sum up, we know that blood creatinine is generally the test of the normal renal function is one of the indicators, there is an inevitable link between them. Therefore, it is necessary to take remedial measures in time after the high creatinine is found!